BDBM50026612 BIBF-1120::Nintedanib::US10981896, Compound Nintedanib::US11046672, Nintedanib::US11208381, Nintedanib::Vargatef
SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1
InChI Key InChIKey=XZXHXSATPCNXJR-ZIADKAODSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 50026612
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
The University of Texas At Austin
Curated by ChEMBL
The University of Texas At Austin
Curated by ChEMBL
Affinity DataKi: 5.60nMAssay Description:Inhibition of His6-tagged MELK catalytic domain (1 to 340 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells using Bcl-GL as s...More data for this Ligand-Target Pair
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
The University of Texas At Austin
Curated by ChEMBL
The University of Texas At Austin
Curated by ChEMBL
Affinity DataKd: 4.90nMAssay Description:Binding constant for MELK kinase domainMore data for this Ligand-Target Pair
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
The University of Texas At Austin
Curated by ChEMBL
The University of Texas At Austin
Curated by ChEMBL
Affinity DataIC50: 43nMAssay Description:Inhibition of His6-tagged MELK catalytic domain (1 to 340 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells using Bcl-GL as s...More data for this Ligand-Target Pair
TargetMaternal embryonic leucine zipper kinase(Homo sapiens (Human))
The University of Texas At Austin
Curated by ChEMBL
The University of Texas At Austin
Curated by ChEMBL
Affinity DataIC50: 43nMAssay Description:MELK and its substrate, Bcl-G were both recombinantly expressed and purified for use in screening assays (See Methods). 752 compounds from an in-hous...More data for this Ligand-Target Pair